EU-OPENSCREEN-DRIVE chemoproteomics and MSI open call pipeline offers:
- Mass Spectrometry Imaging (MSI) for compound disposition studies.
- Access to appropriate in-vitro and in-vivo models and samples to support tissue disposition type studies for Mass Spectrometry Imaging applications.
- Affinity-based target identification including synthesis of chemical probes, affinity purification and proteomics analysis.
- Other advanced target ID methods based on cellular thermal shift assays (CETSA) and iso-thermal dose response (ITDR) experiments.
- Standard proteomics methods including the quantitative analysis of proteins and their post-translational modifications by using label-free and label-based quantification strategies.
- Data processing and bioinformatics data interpretation pipelines including statistical analysis.
Applicants will be asked to provide a detailed description of the objectives of their project, and to fulfil specific pre-requisites such as
- confirmed compound cellular or organismal activity in the low µM range;
- ideally (but not mandatory) preliminary Structure Activity Relationships (SAR) identified;
- ideally (but not mandatory) having an SAR-informed synthesis of linker derivatives for functional immobilization in place;
- ideally (but not mandatory) having an inactive compound from the same series available,
- ideally, for MSI studies, having a well-characterised pharmacokinetic profile (e.g. half-life, bioavailability, maximum tolerated dose, dosing route, initial formulation) and
- granted access to relevant biological material. All project pre-requisites for application can be found below.
Deadline for proposal submissions:
May 17th, 2021, 16:00 (CET)
For specific questions please contact:
firstname.lastname@example.org or email@example.com