EU-OPENSCREEN-DRIVE Newsletter No 02 - April 2021

Chemoproteomics and Mass Spectrometry Imaging Call 2021 (open until May 17th 2021, 16:00 CET, funded)

EU-OPENSCREEN-DRIVE offers trans-national access to target-based and phenotype-based workflows, proteomics and related advanced mass spectrometry-based technologies, with a focus on Mass Spectrometry Imaging (MSI). Our chemistry sites collaborate with partners that have a proven track-record in probe development, target deconvolution and MSI.

The project will support at least 3 successful applicants, providing target identification and compound disposition studies. Users from institutions within European member states and associated countries, and up to one user from a non-EU country, can apply for access to seven advanced proteomics and MSI facilities across Europe.

The complete call text is available at:

Call overview

EU-OPENSCREEN-DRIVE chemoproteomics and MSI open call pipeline offers:

  • Mass Spectrometry Imaging (MSI) for compound disposition studies.
  • Access to appropriate in-vitro and in-vivo models and samples to support tissue disposition type studies for Mass Spectrometry Imaging applications.
  • Affinity-based target identification including synthesis of chemical probes, affinity purification and proteomics analysis.
  • Other advanced target ID methods based on cellular thermal shift assays (CETSA) and iso-thermal dose response (ITDR) experiments.
  • Standard proteomics methods including the quantitative analysis of proteins and their post-translational modifications by using label-free and label-based quantification strategies.
  • Data processing and bioinformatics data interpretation pipelines including statistical analysis.

Applicants will be asked to provide a detailed description of the objectives of their project, and to fulfil specific pre-requisites such as

  1. confirmed compound cellular or organismal activity in the low µM range;
  2. ideally (but not mandatory) preliminary Structure Activity Relationships (SAR) identified;
  3. ideally (but not mandatory) having an SAR-informed synthesis of linker derivatives for functional immobilization in place;
  4. ideally (but not mandatory) having an inactive compound from the same series available,
  5. ideally, for MSI studies, having a well-characterised pharmacokinetic profile (e.g. half-life, bioavailability, maximum tolerated dose, dosing route, initial formulation) and
  6. granted access to relevant biological material. All project pre-requisites for application can be found below.

Deadline for proposal submissions:
May 17th, 2021, 16:00 (CET)

For specific questions please contact: or

Detailed Information


Involved scientific partners:

Application requirements and submission details:

Proposal guidelines:

General enquiries

Phone: +49 (0)30 9489 2422
Email:  drive(at)

Robert-Rössle-Str. 10, Building C87
13125 Berlin, Germany

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European project funding

This project receives funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 823893.

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