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Thyroid Gland Comparing: from Synthetic to Natural Source

“The body normally has difficulty recognizing synthetic drugs, making them harder to metabolize and for this reason are more likely to induce toxicity and adverse side effects.”


What is absorbed to the cells is far more important than what’s consumed in the gut. This is true with most things in life from the food we eat to the medications taken, be it prescription drugs or naturally sourced nutraceuticals. A medicine that is beneficial for one may be poorly tolerated by another, while many taking synthetic medication may experience genetic mutations.

The human body is complex and interlinked with other endocrine gland stimulation. Taking a single gland—especially when synthetically based and created in a lab opposed to one naturally occurring—,  may cause an imbalance with other endocrine glands involved: hypothalamus, pituitary gland, thyroid, parathyroid, adrenal glands, pineal glands, reproductive glands (which include the ovaries and testes) and the pancreas.

Synthetic or the natural plant or animal nutraceuticals are a controversial subject and one of debate for several decades. Synthetic drugs are designed to mimic what nature naturally provides and is often produced with harsh chemicals. The body normally has difficulty recognizing synthetic drugs, making them harder to metabolize and for this reason are more likely to induce toxicity and adverse side effects. According to an article written in Very Well Health, levothyroxine, the synthetic in active form of the hormone thyroxine T4, must first be converted within the body to triiodothyronine T3 before being absorbed to the cells. Levothyroxine is considered the standard of care for conventional physicians.

New research is identifying genetic defects known as deiodinase polymorphisms that make a subset of patients less effective at converting T4 into T3. These studies suggest that levothyroxine alone is inadequate for these patients.
  • Fifteen recent studies have evaluated levothyroxine plus liothyronine treatment for hypothyroidism. A number of the studies found improved mood, quality of life, and cognitive factors in patients taking the combination therapy, compared to levothyroxine alone.
  • Other studies have shown that using supplemental T3 results in lower cholesterol levels, a greater reduction in body weight, and better resolution of symptoms, without any additional risks when compared to levothyroxine alone.
Desiccated thyroid extract a safe alternative to levothyroxine in hypothyroidism [1]

According to Thanh D. Hoang, DO, staff endocrinologist of the Walter Reed National Military Medical Center in Bethesda, Md. “desiccated thyroid extract could be a viable treatment option for patients with symptoms of hypothyroidism, despite normal TSH (thyroid stimulating hormone - ) measurements while taking levothyroxine alone. Further, the desiccated thyroid extract yielded superior weight loss compared with levothyroxine.”
The randomized, double blind, crossover study examined the efficacy of both drugs, according to Endocrine Today. Seventy patients aged 18 to 65 years with primary hypothyroidisms were randomly assigned to either desiccated thyroid extract (DTE) or levothyroxine for 16 weeks. According to data, patients assigned to DTE lost 3 lb, compared with those assigned levothyroxine (172.9 lb vs. 175.7 lb, P<.001).

“We didn’t find any differences in the neurocognitive measurements between the two therapies, but at the end of the study we did ask our patients which regimen they preferred.” At the end of the 16-week study, 34 patients (48.6%) preferred DTE therapy, whereas 13 (18.6%) preferred levothyroxine; 23 (32.9%) did not specify a preference, he said. Further analysis confirmed those who preferred DTE lost even more weight over a 4-month period. “We now know that once-daily desiccated thyroid extract is a safe alternative treatment for patients with hypothyroidism who are not satisfied with levothyroxine treatment. It’s an option for them to try, and also desiccated can cause modest weight loss in these patients as well,” Hoang said.

Hypothyroidism incidence in and around pregnancy [2]

Thyroid hormone imbalance is far reaching and results in multiple health concerns from depression to lack of energy or side effects of pregnancy, and it also affects a large percentage of women globally, as you can read in the Danish nationwide study reported in European Journal of Endocrinology. Its objective was that “immunological changes in and after a pregnancy may influence the onset of autoimmune diseases, such as Hashimoto’s Thyroiditis disease. An increased incidence of hyperthyroidism has been observed both in early pregnancy and postpartum, but it remains to be studied if the incidence of hypothyroidism varies in a similar way.”

The results showed that “a total of 5220 women were identified with onset of hypothyroidism from 1997 to 2010 (overall IR 92.3/100 000/year) and 1572 women developed hypothyroidism in the period from 2 years before to 2 years after birth of the first child in the study period. The incidence of hypothyroidism decreased during the pregnancy (incidence rate ratio (IRR) vs overall IR in the rest of the study period: first trimester: 0.89 (95% CI: 0.66–1.19), second trimester: 0.71 (0.52–0.97), third trimester: 0.29 (0.19–0.45)) and increased after birth with the highest level at 4–6 months postpartum (IRR 3.62 (2.85–4.60)).”

As conclusion, “the incidence declined during pregnancy followed by a sharp increase postpartum. Notably, hypothyroidism as opposed to hyperthyroidism showed no early pregnancy increase.”

Solution for hypothyroidism and hyperthyroidism

Raw desiccated whole thyroid gland concentrates derived from non-GMO grass-fed bovine, that is non-medicated and hormone free, could help restore the balance needed for those with both hypothyroidism and hyperthyroidism. Thyrodine® is a proprietary preparation without chemical residue, safe, effective and a natural source of iodine. A 4 year achievement, and licensed by Health Canada.

  • Almekinder, Elisabeth RN, BA, CDE. (2018) The Relationship Between Diabetes And Thyroid Disorder.
  • Andersen S. L. Carlé A., Olsen J., Laurberg P. (2016) Hypothyroidism incidence in and around pregnancy: a Danish nationwide study. In European Journal of Endocrinology. Volume 175, Issue 5, p. 387–393.
  • Hoang Thanh D. (2013) Desiccated thyroid extract a safe alternative to levothyroxine in hypothyroidism. Presented at: The Endocrine Society Annual Meeting and Expo; June 15-18, 2013; San Francisco.
  • Leung, Angela M. MD, MSc (2013) Hypothyroidism. Desiccated thyroid extract vs Levothyroxine in the treatment of hypothyroidism (Summary) Clinical Thyroidology for the Public. Vol 6, Issue 8, p. 3.
[1 ]Hoang, T. 2013.
[2] Andersen S. L. Carlé A., Olsen J., Laurberg P. 2016, 388.

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