IVDD Screening in Denmark
An article, based on a recently published research paper, has been published in the Danish Veterinary Journal DVT. In summary, it says:
Disc herniation is a complex inherited, painful disorder that poses the biggest health problem among dachshunds. The breeding work has for years been based on back x-rays to determine the number of calcifications (K-number). Calcified discs can develop into prolapse, and the K number is therefore indicative of the risk. A mutation on chromosome 12 has recently been associated with the risk of disc herniation, and based on this finding, a DNA test has been offered.
In this article, we compare the validity of the K-number and the DNA test result, respectively, as a tool in the effort to reduce the incidence of disc herniation in dachshunds.
In a questionnaire survey of 122 back-photographed dachshunds, researchers examined the accuracy of the current breeding programme based on this method. Dogs with ≥ 5 calcifications are 14 times more likely to develop disc herniation than dogs with <5 calcifications. Back x-rays and the limit value of <5 calcifications are therefore a good selection and prognostic tool.
For comparison, researchers examined the validity of the DNA test by genotyping 151 back-screened dachshunds. The frequency of the mutation allele was very high - even among those with few calcifications. Only seven wire-haired and one smooth-haired dachshund were free of the mutation. As the DNA test would thus exclude almost all dachshunds from breeding, including those with few or no calcifications, it cannot be recommended.
[Translated by Google Translate from Danish]
Read our UK summary of this, here.