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The role of RHOE Protein in the proliferation of neural progenitor cells, by Fulgencio Ruso 

07/03/2014, 13h
Seminario en el Salón de Actos 1 del CIPF

Fulgencio Ruso

Neuronal development is crucial for our mental health and perturbations in the signaling and morphology may lead to important cognitive injury. In this regard, Rho proteins play a key role in several aspects of neuronal development and also in the pathogenesis of neurodegenerative diseases. RhoE is an atypical member of this family whose specific function in the development of the nervous system is still unknown. Our goal is to investigate the role of RhoE in the neurogenesis process, specifically on the stem cell proliferation in the subventricular zone (SVZ), by using the neurosphere culture system. To address our studies we have a mouse model lacking RhoE expression which exhibits an early postnatal mortality, neuromotor and neuromuscular alterations, demyelination and axonopathy, indicating an abnormal development of the nervous system. Our results show an increase in both the proliferation rate and the survival of neural progenitor cells. We have also observed that the absence of RhoE alters the expression of certain proteins in neural progenitors, such as the GSK3. Understanding the molecular mechanisms involved in the neuronal development and function may provide better strategies for the treatment of neurodegenerative disorders.

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