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Summer 2014

PROGRAM NEWS

What's in the IACUC policies?

Do you know what’s in the IACUC’s Mouse Breeding Cages policy? Are you familiar with the requirements stated in the Inhalation Anesthesia Machine policy? Do you visit the IACUC Policies website regularly to stay abreast of policy changes that provide clarification and guidance to meet regulatory requirements?
 
One method the IACUC employs to assess the overall quality of the animal care and use program during semiannual inspections is to quiz personnel on policies that might apply to the research being conducted. If you are performing CO2 euthanasia, do you know that confirmation of death is required as stated in the policy CO2 Euthanasia of Rodents Including Guinea Pigs? If you are performing survival surgery, do you know the requirements for sterilization of surgical instruments as stated in the policy Autoclave Verification and Validation for Survival Surgical Equipment?
 
During semiannual inspections the IACUC sometimes discovers that investigators and staff are not aware of the requirements set forth in these and other policies regarding the use of animals at Ohio State. Two common issues noted during inspections include deficiencies in documentation and descriptions of survival surgery procedures.
 
Several policies explicitly state requirements about documentation: The IACUC surgery policies (Rodent Surgery and Surgery Policy for USDA Covered Species) list several requirements about which personnel performing surgery should be knowledgeable. For example, both policies contain explicit requirements regarding analgesia, record keeping, surgical site preparation and removal of non-absorbable sutures and staples:
  • Analgesia must be provided to animals that are likely to experience post-procedural pain unless exceptions are approved by the IACUC
  • Investigators are responsible/must maintain accurate records of anesthesia, surgery and post-operative care, including analgesic administration
  • Hair/fur must be removed and the surgical site must be scrubbed three times with a skin disinfectant, alternating each disinfectant scrub with a scrub of sterile water or 70% isopropyl alcohol
  • Non-absorbable sutures and staples must be removed at 10-14 days
These policies differ slightly on requirements for surgical garb:
  • Surgeons performing survival surgery on non-USDA rodents must wear a mask, clean gown and sterile or properly disinfected exam gloves
  • Surgeons performing survival surgery on USDA species must wear a mask, bonnet, sterile gloves and gown
In preparation for an upcoming semiannual inspection, personnel are encouraged to review and follow the policies that apply to the activities on their approved protocols. Quality improvement specialists in the Office of Responsible Research Practices (ORRP) provide educational outreach and a review of policies specific to activities on approved animal protocols (contact IACUCInfo@osu.edu). Also, ULAR training staff provide hands-on training for surgery or euthanasia techniques (contact ulartraining@osu.edu).

Successful USDA inspections

Representatives from the United States Department of Agriculture Animal and Plant Health Inspection Service conducted unannounced inspections of housing facilities and animal use locations at the Ohio Agricultural Research and Development Center (OARDC) in Wooster in June and at Ohio State’s main campus in Columbus in July. No compliance issues were identified during inspections at either location.

Congratulations

Congratulations to Mackenzie Nicholas, who won the American Association for Laboratory Animal Sciences (AALAS) Technician of the Year Award, and Crystal Sims, who won the District 5 AALAS Animal Technician Award.

IACUC POLICIES

Updates

All of the policies developed by the Ohio State IACUC to assist investigators and staff with their research are available on the IACUC Policies webpage. These polices are reviewed on a regular basis to ensure that they continue to meet the regulatory requirements.
 
New - Expired Medical Materials Policy: This policy describes the use of expired materials and applies to all live vertebrate animals.
  • Expired analgesics, sedatives, anesthetics and euthanasia solutions must not be used, even in acute terminal procedures
  • Expired medical materials may be re-sterilized and used for survival surgery provided a new expiration date is clearly labeled on the package
  • Expired medical materials may be used for acute terminal procedures but must be segregated from non-expired materials and clearly labeled as “Expired for Acute Terminal Studies Only”
 New - Antibody Production Policy: This new policy combines information from two separate policies that previously described requirements associated with the production of monoclonal and polyclonal antibodies.
 
Revised - Adverse Effects and Early Removal from Study: This revision was primarily administrative, but it is important to note that this policy was formerly known as the Early Removal Criteria and Non-CO2 Euthanasia policy, and that information and criteria from the Tumor Production policy, which was withdrawn, was incorporated into this one.
 
Revised - Reporting of Temperature Excursions in Animal Housing Locations: This policy was revised to clarify that any temperature excursions that fall outside the Guide recommended range or the approved range in the SOP/SMP must be reported to a supervisor, principal investigator, facility manager and/or Service2Facilities, and that all such reporting actions must be documented.
 
Revised - Rodent Identification Policy: This policy was formerly known as the Methods of Rodent Identification policy and was revised to limit the number of toes that may be removed to one digit per rodent from the hind paw only. As a reminder, toe-clipping must be scientifically justified and approved by the IACUC when other individual identification methods are not feasible.

REMINDERS

Conflict of interest disclosure

Remember that the conflict of interest disclosure must be updated annually to comply with federal and state regulations, accreditation requirements and Ohio State policies. In addition, failure to update the disclosure can have an impact on timely processing of study team changes and submissions on new or renewal protocols. The 2014 conflict of interest disclosure can be completed by logging in at go.osu.edu/coi.

CITI program training

Remember that both the Animal Care and Use course and the Occupational Health and Safety Training course are now available in a single course, Working with the IACUC, found on the CITI program portal. Completion of Working with the IACUC satisfies both requirements. The CITI portal and instructions for enrolling can be found on the Office of Research Training and Education website, or CITI can be accessed directly by logging in at go.osu.edu/citi.

Listing agents in protocols

Investigators are reminded to be as specific as possible when listing agents in the protocol activities section. Using general descriptions such as "bacteria" or acronyms for chemical or drug names makes it very difficult for the IACUC to conduct a complete review and hazard assessment of the protocol without requesting additional information. The approval process can ultimately be accomplished much quicker if the specific agent information is provided initially.

E-PROTOCOL TIPS

Changing the study team

Changing the study team is a two-step process. Anyone on the protocol can complete the first step by clicking on the Propose Study Team Change link in e-Protocol and adding the new personnel. Only the PI can complete the second step of clicking on the Submit Study Team Change link. All personnel training requirements must be up-to-date before the second step can be completed. Anyone can click on the Check Study Team Requirements link to ensure all requirements are up-to-date before the PI finalizes the change.

Animal use location room numbers

If protocol activities are being performed inside any ULAR vivarium, a room number is not required. Simply enter ULAR into the Room Number field. Entering ULAR to indicate any housing or procedure room inside the vivarium is sufficient to ensure proper IACUC oversight, and it gives investigators the flexibility to use other rooms within the facility depending on availability.

Amendment and annual reviews

Amendments and annual reviews are two separate functions within e-Protocol and can be created, submitted and reviewed at the same time, even if they are both for the same protocol.

Reporting sponsor(s) and project numbers

Fiscal officers frequently check for funding information in
e-Protocol. Be sure that information listed in the Funding Source section of the protocol form has the most up-to-date and accurate information, especially when trying to place orders or when submitting a grant.

STAFF PROFILES

Peter McKinley

Peter McKinley, a certified assistant laboratory technician, is a laboratory animal technologist in ULAR. McKinley came to Ohio State in June of 1989 as a lab animal aid in Graves Hall. Over the past 25 years he has worked with a variety of species, including reptiles, rodents, opossums, raccoons, monkeys and non-human primates. In his current position, McKinley is a facility building leader where he ensures the daily care and upkeep of the vivarium located in Postle Hall. He also assists and supports investigators and research personnel who house animals in the facility. One of Pete’s favorite memories during his tenure at Ohio State is the opportunity he was given to teach about opossums in a presentation. He also garners a great deal of satisfaction knowing that he is part of the process that leads to new research discoveries and that he assists others as they become medical professionals and researchers. McKinley has been an active member of AALAS since 2002.

Joshua Filson

Joshua Filson joined the Ohio State animal care program team in December 2011 as a facility manager. Filson came to Ohio State after completing an Associate of Science degree in Pre-Agricultural Education from The Ohio State University Agricultural Technical Institute and a Bachelor of Science degree at Ohio State in Animal Science. In addition, he was a beef heifer development manager for the Virginia Department of Corrections and an organization director with the Ohio Farm Bureau Foundation for Hardin, Logan and Wyandot counties before coming to Ohio State. In his current position, Filson manages and oversees the daily operation of ULAR facilities in the Davis Heart and Lung Research Institute, Graves Hall, Postle Hall and the Psychology Building. He also works closely with veterinary faculty, the IACUC, and research investigators and staff to facilitate facility operations and research support while also meeting the applicable rules and regulations. He was president and executive director of the Alpha Gamma Sigma national executive council and board of directors from 2008 to 2010, holds credentials in bovine artificial insemination and reproductive methods and has been an active member of AALAS since 2011. In his free time, Josh enjoys spending time with his wife and two sons, farming and golfing.
IN THIS ISSUE
  • What's in the IACUC policies?
  • Successful USDA inspections
  • Congratulations
  • IACUC policies updates
  • Reminders
  • e-Protocol tips
  • Staff profiles
EVENTS
Meeting planner

Upcoming IACUC meeting dates

September 19
October 17
November 21

All sessions take place at 12:30 p.m.
 
Additional information about submission deadlines can be found on the IACUC meetings webpage.

ULAR training sessions

Facility Introduction and Mouse Overview
 
September 11
September 23
October 9
October 28
November 13
November 25

All sessions take place at
1 p.m.
 
Rodent Survival Surgery
 
September 16
October 21
November 18
 
All sessions take place at 10 a.m. 

Class sizes for ULAR training sessions are limited to 15 registrants.
 
To register: Call 292-5094, email ulartraining or visit the research calendar.
 
Individual sessions may be arranged for protocol-specific techniques by completing the Training Request Form on the ULAR training webpage and emailing it to the ULAR training coordinator at ulartraining@osu.edu.
RESOURCES

Office of
Research Units

© 2014 The Ohio State University – Office of Research
Office of Responsible Research Practices – Institutional Animal Care and Use Committee
Research Administration Building, 1960 Kenny Road, Columbus, OH 43210
Phone: 614-688-8457 | Fax: 614-688-0366 | Email the IACUC

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