FOCUS ON THALASSEMIA AND IRON-DEFICIENCY ANEMIA
PREVALENCE OF HEMOGLOBINOPATHY AMONG ANEMIC INDIVIDUALS IN METRO MANILA
Anemia due to iron deficiency is a public health problem in the Philippines; and iron fortification and supplementation programs have been implemented to address this problem. However, recent studies suggest that in Southeast Asia, hemoglobinopathies also contribute significantly to the burden of anemia.
Anemia due to hemoglobinopathy requires blood transfusion and iron chelation, and is not amenable to dietary iron intervention. There is therefore an urgent need to discriminate anemic individuals with nutritional iron deficiency from those with hemoglobinopathy.
ILSI SEA Region, in collaboration with the Food and Nutrition Research Institute (FNRI), Philippines, developed this research project to investigate thalassemia and other hemoglobinopathies as an underlying cause of anemia among Filipinos, using data from the 2013 National Nutrition Survey. The researchers aimed to estimate the prevalence of anemia and the proportion of thalassemia and hemoglobinopathies among anemic individuals in Metro Manila. In addition, the research project also examines hemoglobin fractions and red blood cell parameters of anemic individuals with iron deficiency and hemoglobinopathy; they also examine the intake of iron supplements among anemic individuals with hemoglobinopathy.
ILSI SEA REGION EVENTS UPDATE
ILSI SEA REGION ANNUAL MEETING 2016
Seminar on Food Consumption Data and Dietary Assessment
25 - 26 April, 2016, Hilton Hotel, Singapore
ILSI Southeast Asia Region will hold its 2016 Annual Meeting back to back with the Scientific Seminar Food Consumption Surveys and Dietary Assessment in Singapore on April 25 & 26, at Hilton Singapore. The half-day Food Consumption Surveys and Dietary Assessment seminar will be held in the afternoon of April 26. More information on the seminar will be updated here.
Genetic Hemoglobin Disorders a Major Predictor of Hemoglobin Concentration in Women of Reproductive Age in Rural Cambodia
In an article
published in the Journal of Nutrition
from the American Society for Nutrition
, factors associated with anemia and the relations between hemoglobin disorders and other iron biomarkers among women in rural Cambodia were investigated. Blood samples were obtained from 450 women, aged 18-45, living in rural Cambodia. In their findings, 54% of the women had a genetic hemoglobin disorder. Prevalence of iron deficiency anemia was 14.2% among women with hemoglobin disorder, while the prevalence iron deficiency anemia among the women without hemoglobin disorders was only 1.5%. The authors concluded that genetic hemoglobin disorders are a major predictor of hemoglobin concentration, as compared to iron deficiency, in these women. The full article can be accessed here
Targetting α-globin in treatment of β-thalassemia
A recent review
conducted by the Medical Research Council
in the University of Oxford reviewed evidence that increasingly strong evidence that reducing α-globin expression may ameliorate clinically severe forms of β-thalassemia. This included clinical and genetic evidence accumulated over the past 30 years which strongly support the idea of reducing α-globin as a therapeutic option for β-thalassemia. This calls for researchers to explore treatment of thalassemia through gene therapy, as current treatment of thalassemia is still far from ideal, requiring lifelong transfusion or allogeneic bone marrow transplantation. The complete report is available HERE
Disease severity scoring system for adult and pediatric NTDT patients
In an article published in the European Journal of Internal Medicine, a team of Non-Transfusion-Dependent Thalassemia (NTDT) experts from Europe and Thailand developed a new disease severity scoring system for adult and pediatric NTDT patients. The system is based on 20 parameters that are most pertinent in defining disease severity. An additional six parameters were selected specifically for pediatric patients. Consensus of expert opinion was used to establish the selected methods of assessment for each parameter, based on feasibility and availability of technology, cost containment, and avoidance of patient risk. This new scoring system is proposed to be developed into a practical tool for clinical use. The complete article is available HERE.
Discriminating Thalassemia syndromes and Iron deficiency anemia
A team from the Thalassemia Research Center in Thailand discovered a variety of discrimination criteria to distinguish between thalassemia syndromes and iron deficiency anemia. This was done through analyzing red cell and reticulocyte parameters from samples of these two conditions. 414 samples of various types of thalassemias and IDA were collected for analyzing. The parameters included mean cell volume (MCV), mean cell hemoglobin content (MCH), red blood cell counts (RBc) and the microcytic and hypochromic red cells ratio (M/H ratio). Reticulocyte counts were also used to determine response to iron therapy. The full article can be found HERE.