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Drug Induced Vascular Injury:
An Often Complicated Issue 

Drug-induced vascular injury (DIVI) is a major concern for development of new and novel therapies.  Efforts to identify biomarkers consistent with DIVI have not been successful, largely attributed to the complex nature of the vascular responses to injury and a lack of understanding of the mechanisms controlling these responses.  Recent publications on biomarkers of DIVI highlight some of the pitfalls in these efforts.

Wide Ranging Causes
The causes of vascular injury are wide ranging from alterations in hemodynamics to targeted toxicity on components of the vasculature (e.g. endothelial and smooth muscle cells) and to inflammatory and immune-mediated alterations, leading to secondary effects on the vasculature.  The characterization of the vascular findings are still considered essential in determining their relationship to treatment and to understanding their potential mechanism.  Hemodynamically active compounds typically target the smooth muscle cell of the media.


Distribution and Morphology
The distribution and morphology of the vascular findings associated with vasoactive-induced arterial lesions in association with vasodilator and/or positive inotrope-induced lesions are well recognized.  These vasoactive-induced arterial lesions generally involve the coronary arteries and are associated with significant medial necrosis and hemorrhage.

Blog: Drug Induced Vascular Injury (DIVI)                 

Profiled Team

Paul W. Snyder    
DVM, PhD, Diplomate ACVP, Fellow IATP
Manager, EPL Midwest / Senior Pathologist

Amy Brix   
DVM, PhD,
Diplomate ACVP
Senior Pathologist
Rebecca Moore     
DVM, Diplomate ACVP
NC Histology Laboratory Supervisor / Senior Pathologist
Torrie Crabbs  
DVM, Diplomate ACVP
Senior Pathologist
 

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41st NSH Annual Symposium
Aug 28-Sep 2, 2015
Gaylord National Resort and Convention Center
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ESTP: 13th European Congress of Toxicologic Pathology
Sept 22-27, 2015
Guildford, Surrey, UK

STP 2015 Annual Meeting
American College of Veterinary Pathologists (ACVP), American Society for Veterinary Clinical Pathology (ASVCP), and the Society of Toxicologic Pathology (STP) Joint Annual Meeting
October 17-21, 2015
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November 1-5, 2015
Salt Lake City, UT

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