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EPL Focuses on Ocular Pathology
The eye and the ocular adnexa are common target organs in toxicology studies, but the appropriate evaluation of ocular tissues is a specialized endeavor.  Compared to routine toxicity studies, ocular toxicity studies require methodological modifications at almost every stage from study design to the final pathology report.

For example, at necropsy, the fragile nature of many ocular tissues requires particularly careful handling, very rapid exenteration, and specialized fixatives such as modified Davidson’s solution.  The left and right eyes and their adnexa should be identified and stored in separate labeled containers.  The globes should be marked (with sutures, indelible ink, etc.) in such a manner that the superior-inferior and nasal-temporal aspects remain identifiable.  

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EPL Employee Highlight  Dr. Margarita Gruebbel, Senior Pathologist

Dr. Gruebbel is a study pathologist for acute and chronic GLP studies (rats, mice, dogs, rabbits, NHP, and other species) for EPL's commercial clients ranging from large pharmaceutical companies to small biotechnology firms. Her focus is in ophthalmic pathology studies along with ...  Bio


Profiled Team

Dr. Jerry F. Hardisty    
DVM, Diplomate ACVP, Fellow IATP  
CEO / President / Senior Pathologist 
Dr. Margarita Gruebbel    
Senior Pathologist     
Dr. John Curtis Seely  
Senior Pathologist 
Dr. Cynthia Shackelford
     
Senior Pathologist

Dr. Kathleen Funk    
Manager, Virginia Laboratory Operations / 
Senior Pathologist 

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2014 Editions

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PH (919) 998-9407  Ext 614

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Comparative Anatomy of the Eye
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Meet the EPL Team
STP 2014 Annual Meeting
June 22-26, 2014
Marriott Wardman Park
Washington, DC
Sponsor Monday evening reception

NSH 40th  Annual Symposium/Convention
Aug 21-27, 2014
Austin, TX
Society for Neuroscience Annual Meeting 2014
November 15-19, 2014
Walter E. Washington Convention Center, Washington, DC

Developmental & Reproductive Pathology

The evaluation of potential effects of a test article on reproductive function and development of offspring which requires a high level of scientific expertise and experience. The pathologists at EPL ... More

Medical Device Pathology

EPL pathologists have many years of experience with evaluation of the irritation potential of solid devices made from a variety of materials, as well as injectibles and leachables.  Beyond standard irritation tests, our pathologists also evaluate  ...  More 

Inhalation Pathology

EPL has the ability to perform histology and histopathology in accordance with the Good Laboratory Practice guidelines as prescribed by U.S. FDA, U.S. EPA, and OECD. Our expertise in the evaluation of respiratory tract tissues ... More
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