CDCN Monthly Newsletter - April 29, 2015
Accelerating Research & Treatment for Castleman Disease
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      THE ACCELERATOR: CDCN's Newsletter

CDCN and UAMS Launch Study to Uncover Castleman Disease (CD) Pathways

The Castleman Disease Collaborative Network (CDCN) and Dr. Frits Van Rhee at the University of Arkansas for Medical Sciences (UAMS) are collaborating to conduct a serum proteomics study that will measure the levels of inflammatory proteins in CD. Eight patients have contributed samples to this study, which is a top priority for the field, because important diagnostic and therapeutic biomarkers may be identified.

HHV-8-negative or "idiopathic" Multicentric Castleman disease (iMCD) involves hyperactivation of the immune system, pro inflammatory protein ("cytokine") release, and organ dysfunction. The trigger for the immune activation is unknown, and the pro inflammatory proteins ("cytokines") released, which drive the entire disease, have not been systematically measured. Email if you are a CD patient that is interested in providing samples to help advance research.
Castleman Warrior of the Month - Chris Kimura
Chris was diagnosed with Multicentric Castleman Disease in 1994, and since then has joined the fight to raise awareness and search for a cure. He has battled with this disease for over 20 years, and shared with us that he still feels very blessed to have his amazing wife and stepson by his side through it all. To read the full interview click here.
Are you a patient or loved one? Ready to join the fight? It’s easy to become a Castleman Warrior! Please click here to learn more.

Will You Support Our Events to Fight Back Against CD?

Patients from around the world and the CDCN Leadership Team have been working very hard to raise enough funds to launch three studies aimed to advance Castleman Disease research and treatments. We have already raised over $50,000 through our Castleman Warrior Program and our Knockout Castleman Campaign, a partnership with the student body and clubs at Wharton Business School. Our goal is to raise $200,000 in the next 6 months to fund our next three critical studies at the top of our international research agenda.

Right now we have an incredible opportunity to have every dollar that is donated to the CDCN to be matched by the UPenn Orphan Disease Center (ODC) between now and May 9th. Please donate here so that your gift will be doubled. The ODC is putting on the Million Dollar Bike Ride on May 9th. There are several ways you can get involved:

  • Sign up here to become a Castleman Warrior
  • Contact us if you're interested in putting on a fundraising event within your local community
  • Participate in CDCN events, such as the upcoming Broad Street Run (Philadelphia), May 3rd
  • Click here to donate directly through our website
  • Consider joining our CDCN Leadership Team

Co-Founder Shares About the CDCN's Progress While
Flipping the Research Model on its Head 

Dr. David Fajgenbaum, co-founder & Executive Director of the Castleman Disease Collaborative Network and an Adjunct Assistant Professor of Medicine at UPenn, addressed the Wharton Health Care Business Conference on February 20, 2015. His talk, "Flipping the old model on its head," reviews the CDCN's work to advance research for Castleman disease and to create a model for advancing research for deadly illnesses. Check out: to watch the 15 minute lecture.

Meet Our Managing Director of Research:
Jason Ruth, PhD

Jason Ruth, PhD, is the CDCN's Managing Director of Research and a postdoctoral fellow in Levi Garraway's laboratory at the Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard. Jason met Dr. David Fajgenbaum at Penn Med, where his compassion and sense of humor made him everyone's close friend. Dave's battle with Castleman disease inspired him to apply his research experiences and expertise to help cure Castleman disease. Since then, Jason has been an integral  member of the CDCN team. He leads short-term and long-term research strategies and ensures that high priority projects are executed in a timely and scientifically rigorous manner.

Jason shared "Our research projects are designed with the patient in mind, and we have a clear path for how our research will help patients. With support from patients and their loved ones, we will be able to fund the critical research projects that will ultimately help us cure Castleman Disease." Feel free to reach out to Jason by emailing
Copyright © 2015 Castleman Disease Collaborative Network - Castleman's Awareness & Research Effort, All rights reserved.

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